| 发明名称 |
HUMAN FGF23 PROTEIN MUTANT LOWERING BLOOD PHOSPHORUS LEVEL |
| 摘要 |
A full-length cDNA encoding the human FGF23 protein was isolated, and mutants having a single amino acid substitution in the cDNA were constructed using the mutagenesis method. These mutants had the effect of decreasing the phosphorus level in the blood when expressed in vivo. These mutants and the DNAs encoding them are expected to be useful as therapeutic agents, or employed for gene therapy against hyperphosphatemia.
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| 申请公布号 |
EP1354949(A1) |
申请公布日期 |
2003.10.22 |
| 申请号 |
EP20010271888 |
申请日期 |
2001.12.26 |
| 申请人 |
CHUGAI SEIYAKU KABUSHIKI KAISHA |
发明人 |
ITOH, H.;FUKUSHIMA, N.;SAITO, H.;KUSANO, K. |
| 分类号 |
A01K67/027;A61K38/00;A61K38/17;A61K48/00;A61P3/12;A61P19/08;C07K14/50;C12N5/10;C12N15/10;C12N15/12;G01N33/50;(IPC1-7):C12N15/12;C12P21/02;C12Q1/68;A61K35/76 |
主分类号 |
A01K67/027 |
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