INDOLINESULFONYLUREA DERIVATIVES AND ANTI-CANCER COMPOSITION COMPRISING THE SAME

摘要

PURPOSE: Indolinesulfonylurea derivatives and an anti-cancer composition comprising them are provided. The compounds have improved anticancer activity. CONSTITUTION: (4S) - 1 - (2,3 - dihydro - 1H - indol - 5 - inesulfonyl) - 4 - phenyl - 2 - imidazolidinone derivatives are represented by the formula 1, wherein R is straight or branched chain C1-C6 alkyl, C5-C6 cyclicalkyl, 5 or 6 membered heteroaryl group with or without at least one hetero atom selected from N, S and O, and substituted or unsubstituted by at least one substituent selected from amino, nitro, halogen, hydroxy, cyano, C1-C4 alkyl, C1-C4 alkyloxy, C1-C4 alkylamino, methylsulfonyl and methylsulfanyl, 5 or 6 membered heterocyclic group with or without at least one hetero atom selected from N, S and O, 1-amino-1-(2-thienyl)methyl, or a compound of the formula 11, the formula 12 of -O-R3 or the formula 13 of -X(H)m-(CH2)n-R4.