发明名称 |
Peptides capable of inducing attraction of the axonal growth and their use for treating neurodegenerative diseases |
摘要 |
The present invention is directed to peptides comprising the sequence ASNKL (SEQ ID N DEG 1), inducing attraction of the axonal growth in presence of the semaphorin (Sema3A), L1 and NP-1 proteins and their use for the manufacture of a drug for neuronal/axonal regeneration or for treating neurodegenerative diseases. The present invention also includes a method for identifying a compound able to bind the NP-1, a method for identifying a compound able to revert the repulsory effect of Sema3A on the axonal growth from a suited cell, or methods to screen for molecules capable of blocking Sema3A- induced endocytosis. |
申请公布号 |
EP1354892(A1) |
申请公布日期 |
2003.10.22 |
申请号 |
EP20020076552 |
申请日期 |
2002.04.19 |
申请人 |
CENTRE NATIONAL DELA RECHERCHE SCIENTIFIQUE (CNRS);UNIVERSITE DE LA MEDITERRANEE - AIX-MARSEILLE II |
发明人 |
ROUGON, GENEVIEVE;CASTELLANI, VALERIE |
分类号 |
A61K38/00;A61K38/17;A61P25/28;C07K14/705;G01N33/68 |
主分类号 |
A61K38/00 |
代理机构 |
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代理人 |
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主权项 |
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地址 |
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