FLAVANONE ESTER DERIVATIVES AND COMPOSITION FOR PREVENTION OR TREATMENT OF BLOOD LIPID LEVEL-RELATED DISEASES COMPRISING THE SAME

摘要

PURPOSE: Flavanone ester derivatives and a composition for prevention or treatment of blood lipid level-related diseases comprising them are provided. The compounds are useful for prevention or treatment of blood lipid level-related diseases. CONSTITUTION: Flavanone ester derivatives are represented by the formula 1, wherein R1 is R5CO- group; R2 is H or R5CO- group; R3 is H, CH3, R5CO- or R6 group; R4 is H, OH, R5COO- or OR6 group; R5 is C1-C18 alkyl group; and R6 is C2-C18 alkyl or alkenyl group. A process for preparing the flavanone ester derivatives comprises dissolving naringenin or hesperetin in an organic solvent, inserting 1 to 5 mole equivalency of triethylamine(Et3N) into the mixture, cooling the mixture, inserting 1 to 1.5 mole equivalency of acyl chloride into the mixture, and reacting them for 2 to 10 hours, wherein the organic solvent is tetrahydrofuran or dichloromethane.