发明名称 |
DUAL ACTION 2',5'-OLIGOADENYLATE ANTIVIRAL DERIVATIVES AND USES THEREOF |
摘要 |
Viral infection is inhibited in mammals by administration of metabolically stable, non-toxic 2',5'-oligoadenylate (2-5A) de- rivatives that have a dual therapeutic effect. The compounds activate the intracellular latent 2-5A dependent endoribonuclease RNase L and also inhibit the action of viral DNA polymerases. Conjugates of the 2-5A derivatives for therapeutic delivery are also described: |
申请公布号 |
CA2130926(C) |
申请公布日期 |
2003.10.21 |
申请号 |
CA19932130926 |
申请日期 |
1993.02.18 |
申请人 |
TEMPLE UNIVERSITY - OF THE COMMONWEALTH SYSTEM OF HIGHER EDUCATION |
发明人 |
SUHADOLNIK, ROBERT J.;PFLEIDERER, WOLFGANG |
分类号 |
C07H21/04;A61K31/70;A61K31/7088;A61K31/74;A61P31/12;C07H21/00;C07J43/00;C07J51/00;C08B37/00 |
主分类号 |
C07H21/04 |
代理机构 |
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代理人 |
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主权项 |
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地址 |
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