| 摘要 |
<P>PROBLEM TO BE SOLVED: To provide a syringe type kit pharmaceutical preparation using a serially and sequentially dispensing type syringe, which allows a stable production and sterilization by autoclave after packing and can prevent the generation of air bubbles within the first medicine solution, and also to provide a manufacturing method thereof. <P>SOLUTION: The syringe type kit pharmaceutical preparation comprises an injection cylinder and one or more intermediate sliding valves provided within the injection cylinder. A needle fitting part of the syringe type kit pharmaceutical preparation is sealed hermetically, and the space between the needle side of the injection cylinder and the intermediate sliding valve located nearest to the needle side of the injection cylinder is packed with a medicine solution. When manufacturing the syringe type kit pharmaceutical preparation, the needle fitting part of the injection cylinder is sealed hermetically and the injection cylinder is filled with the medicine solution. The intermediate sliding valve is then inserted into the injection cylinder from an opening on the plunger operation side and is moved to or near the surface of the medicine solution because of the depressurized atmosphere within the injection cylinder. The manufacturing method is characterized in that the depressurized atmosphere is rich in water soluble gas. <P>COPYRIGHT: (C)2004,JPO |
