摘要 |
This disclosure is directed to preparation of individual taste-masked, high bioavailability, high payload, microcapsules by microencapsulation of water-insoluble NSAID drug materials in the substantia l absence of microcapsule agglomerates. These taste-mask ed microcapsules contain a high payload, e.g., about 83+ wt. % of said NSAID) d rug material having high bioavailability and can then be formulated into chewable tablets and liquid aqueous suspensions for medicina l use. Both cellulose acetate phthalate and gelatin are the mivcroencapsulating polymer wall material. Control of pH, controlled additio n of a Hofmeister (lyotropic) salt, microencapsulation o f the water-insoluble NSAID medicament with a liquid phase of both cellulose aceta te phthalate and gelatin microencapsulating material and the subsequent insolubilization of said liquid encapsulating material after it is wrapped around the medicament core with dilute aci d are important process parameters to achieving the proper individual microcapsule s to obtain highly bioavailability task-masked, water-in soluble NSAID drug materials, especially, naproxen and ibuprofen by microencapsulati on alone.
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