| 摘要 |
The invention concerns cylindrical retarded-action tablets hav- ing convex or planar upper and lower surfaces and made of .beta.- phenylpropiophenone derivatives of formula (I) acting as the active ingredient, in which R = n-propyl or 1,1-dimethylpropyl, and pharma- cologically acceptable salts of such derivatives, a) tablet height and diameter, independently of each other, being 1 to 3 mm; b) the con- centration of the active ingredient lying in the range from 81 to 99.9 % by wt. relative to the weight of the microtablet, neglecti ng the weight of any coating present; c) the density of the active ingredient being greater than 1; d) at least 80 % of the active ingredie nt being released between 3 hours and 24 hours when tested using the USP paddle model at 50 rpm; e) the rate of release being virtually indep endent of the pressure used to compress the tablet; f) the tablet containing no ret arding-action auxiliaries but 0.1 to 5 % by wt. of a lu bricant and 0 to 18.9 % by wt. of other usual auxiliaries. The invention also concerns a gelatin capsule containing 3 to 200 such tablets with the same or different release rates, plus a method of producing the tablets.
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