发明名称 |
Neuropilins and use thereof in methods for diagnosis and prognosis of cancer |
摘要 |
The present invention relates to VEGF receptors (VEGFR) and neuropilins such as VEGF165R/NP-1 and NP-2 that are associated with metastatic potential of a malignant cell and their use in the diagnosis and prognosis of cancer. Preferred ones are VEGF165R/NP-1 and NP-2 but any neuropilin or VEGFR, where the constituents share at least about 85% homology with either of the above VEGF165R/NP-1 and NP-2 can be used. More preferably, such constituent shares at least 90% homology. Still more preferably, each constituent shares at least 95% homology.
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申请公布号 |
US6635421(B1) |
申请公布日期 |
2003.10.21 |
申请号 |
US20000583638 |
申请日期 |
2000.05.30 |
申请人 |
CHILDREN'S MEDICAL CENTER CORPORATION |
发明人 |
KLAGSBRUN MICHAEL;SOKER SHAY;MIAO HUA-QUAN;TAKASHIMA SEIJI |
分类号 |
A61K38/00;A61K48/00;C07K14/71;(IPC1-7):C12Q1/68 |
主分类号 |
A61K38/00 |
代理机构 |
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代理人 |
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主权项 |
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地址 |
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