RANOLAZINE PREPARATIONS WITH PROLONGED EFFECT

摘要

FIELD: medicine, pharmacy. SUBSTANCE: invention relates to preparations of ranolazine. The ranolazine preparation of prolonged effect contains uniform mixture of ranolazine and partially neutralized pH-dependent binding substance for a film formation that is insoluble in an aqueous medium usually at pH below 4.5 but it is soluble in an aqueous medium at pH above 4.5. Preparation is useful for administration of ralonazine, 2 times per a day, and can be used for maintaining ranolazine levels in human blood plasma between its concentration 350 and 7 500 ng/ml. Invention provides the development of medicinal form of prolonged effect and maintenance the preparation concentrations for at least 24 h. EFFECT: valuable medicinal and pharmaceutical properties of preparation. 20 cl, 9 tbl