BENZOPYRAN DERIVATIVES SUBSTITUTED WITH SECONDARY AMINES INCLUDING TETRAZOL, PREPARATION PROCESS THEREOF AND PHARMACEUTICAL COMPOSITIONS CONTAINING THE SAME

摘要

PURPOSE: Benzopyran derivatives substituted with secondary amines including tetrazole, a preparation process thereof and pharmaceutical compositions containing the same compounds are provided, which compounds do not induce the decrease of blood pressure and inhibit the damage of nervous cells by oxidation stresses. CONSTITUTION: Benzopyran derivatives substituted with secondary amines including tetrazole represented by the formula 1, stereo isomers thereof or pharmaceutically acceptable salts thereof are provided, wherein R1 is H, F, Cl, Br, CF3, NO2, CN, ORa, OCORa, COORa, NH2, NHS(O)IRa, NHCORa or S(O)IRa; Ra is H, C1-C4 linear or branched chain alkyl or aryl; I is an integer of 0 to 2; R2 is CH2ORa, ORbORc or O(z)O; Rb and Rc are independently C1-C4 linear or branched chain alkyl; Z is C1-C5 linear or branched chain alkyl; R3 is OH, F, Cl, Br, ONO2 or COORa; R4 and R5 are independently H, F, Cl, Br, C1-C3 linear or branched chain alkyl, ORa, CF3, OCF3, NO2, CORa, OCORa, CCOORa or SO3Ra; R6 is hydrogen, C1-C3 linear or branched chain alkyl; n and m are independently an integer of 0 to 2; and * is chiral carbon.