INHIBITORS OF THE S100-p53 PROTEIN-PROTEIN INTERACTION AND METHOD OF INHIBITING CANCER EMPLOYING THE SAME
摘要
Compounds that bind S100 and inhibit the S100-p53 protein-protein interaction and activate the tumor supressor activity of p53, and thus which have an antineoplastic effect are disclosed, as well as methods for identifying these compounds, compositions comprising the same, and methods of using the same to treat cancer.
申请公布号
WO03084475(A2)
申请公布日期
2003.10.16
申请号
WO2003US08678
申请日期
2003.03.28
申请人
UNIVERSITY OF MARYLAND, BALTIMORE;WEBER, DAVID, J.;MARKOWITZ, JOSEPH;CARRIER, FRANCE;MACKERELL, ALEXANDER, D.
发明人
WEBER, DAVID, J.;MARKOWITZ, JOSEPH;CARRIER, FRANCE;MACKERELL, ALEXANDER, D.
