发明名称 |
USE OF A LIPOPEPTIDE OR LIPOPROTEIN AS AN ADJUVANT IN THERAPEUTIC OR PROPHYLACTIC VACCINATIONS |
摘要 |
Disclosed is the use of lipopeptides and lipoproteins as mucosal adjuvants for various vaccinations via mucous membranes, particularly intranasally. Said lipopeptides represent peptides or proteins substituted with 2,3-diacyloxy(2R)-propyl at the amino-terminal cystein of a peptide or protein, preferably S-(2,3-bispalmitoyloxy-(2R)-propyl)cysteinyl peptides derived from mycoplasmas. Said peptides are highly effective even in small doses, produce good immunization results, and increase the IgA level, among others. |
申请公布号 |
WO03084568(A2) |
申请公布日期 |
2003.10.16 |
申请号 |
WO2003EP03497 |
申请日期 |
2003.04.03 |
申请人 |
GBF GESELLSCHAFT FUER BIOTECHNOLOGISCHE FORSCHUNG MBH;GUZMAN, CARLOS, ALBERTO;MUEHLRADT, PETER |
发明人 |
GUZMAN, CARLOS, ALBERTO;MUEHLRADT, PETER |
分类号 |
A61K39/39;A61P31/00 |
主分类号 |
A61K39/39 |
代理机构 |
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代理人 |
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主权项 |
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地址 |
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