发明名称 |
METHOD OF SYNTHESIZING 1alpha-HYDROXY-2-METHYLENE-19-NOR-HOMOPREGNACALCIFEROL |
摘要 |
<p>A method of making 1alpha-hydroxy-2-methylene-19-norhomopregnacalciferol. The method includes the steps of condensing a bicyclic ketone with an allylic phosphine oxide to produce a protected 19-norpregnacalciferol analog, thereafter cleaving the protecting group to form 22-alcohol, converting the alcohol to an ester, reducing the ester to 17beta-isopropyl-19-nor-vitamin D analog, and finally deprotecting the 17beta-isopropyl derivative to form the desired compound.</p> |
申请公布号 |
WO03084925(A1) |
申请公布日期 |
2003.10.16 |
申请号 |
WO2003US09186 |
申请日期 |
2003.03.26 |
申请人 |
WISCONSIN ALUMNI RESEARCH FOUNDATION |
发明人 |
DELUCA, HECTOR, F.;GOWLUGARI, SUMITHRA;SICINSKI, RAFAL, R. |
分类号 |
C07C401/00;(IPC1-7):C07C401/00 |
主分类号 |
C07C401/00 |
代理机构 |
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代理人 |
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主权项 |
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地址 |
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