MOTIF-GRAFTED HYBRID POLYPEPTIDES AND USES THEREOF

摘要

Provided herein are hybrid polypeptides that specifically bind to a disease-associated isoform of a polypeptide involved in diseases of protein aggregation. The hybrid polypeptides can be used for diagnosis and treatment of such diseases. In a particular embodiment, a hybrid protein that specifically binds to the infectious from of a prion (PrP) is provided.