发明名称 |
NUCLEOSIDE VACCINE ADJUVANTS |
摘要 |
Contemplated methods and compositions include a pharmacological composition comprising an antigen and a nucleoside adjuvant that modulates the balance between Type 1 response and Type 2 response in a lymphocyte, wherein the nucleoside is not an 8-substituted guanine nucleoside. In preferred aspects, contemplated adjuvants stimulate Type 1 response and thereby increase a T-cell response, while contemplated adjuvants may also stimulate a Type 2 response and thereby increase a B-cell response. Preferred adjuvants may further comprise a CpG-dinucleotide and/or a CpG-containing oligonucleotide in a synergistic amount. |
申请公布号 |
WO02102307(A3) |
申请公布日期 |
2003.10.16 |
申请号 |
WO2002US18724 |
申请日期 |
2002.06.14 |
申请人 |
RIBAPHARM;LAU, JOHNSON;HONG, ZHI |
发明人 |
LAU, JOHNSON;HONG, ZHI |
分类号 |
A61K31/7056;A61K39/00;A61K39/02;A61K39/12;A61K39/35;A61K39/39;A61P31/04;A61P31/12;A61P33/00;A61P35/00;A61P37/04;A61P37/06;A61P37/08 |
主分类号 |
A61K31/7056 |
代理机构 |
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代理人 |
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主权项 |
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地址 |
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