3'-SUBSTUIERTE NUKLEOSIDDERIVATE

摘要

The invention relates to a 3'-substituted nucleoside derivative represented by the following general formula (1): wherein B means a nucleic acid base which may have a substituent, Z represents a lower alkynyl or lower alkenyl group which may be substituted by a group represented by the formula: in which R, R and R are individually a lower alkyl group or a phenyl group, or an oxiranyl group which may have at least one lower alkyl group, R<1> and R<2> individually represent H or an ester-forming residue capable of easily leaving in a living body, and R<3> is H, a mono- or polyphosphoric acid residue, or an ester-forming residue capable of easily leaving in a living body, with the proviso that the sugar moiety is ribose, or a pharmaceutically acceptable salt thereof. The 3'-substituted nucleoside derivative according to the invention has an excellent antitumor activity and is hence useful for treatment for and prevention of cancers.