ATOPIC DERMATITIS-INDUCING PROTEINS

摘要

Atopic dermatitis-inducing proteins produced by a patient himself/herself are provided as factors causative of atopic dermatitis. Namely, these proteins are atopic dermatitis-inducing proteins which are secreted by the human body and characterized by binding to the own IgE antibody of the human producer and activating mast cells and basophils. More specifically speaking, the above proteins include a salivary acidic proline-rich phosphoprotein having the amino acid sequence represented by SEQ ID NO:2, a prolactin-inducible protein having the amino acid sequence represented by SEQ ID NO:4 and post-translational modifications thereof.