6-(4-SUBSTITUTED-ANILINO)PYRIMIDINE DERIVATIVES, METHOD FOR THE PREPARATION THEREOF AND ANTIVIRAL PHARMACEUTICAL COMPOSITION COMPRISING THE SAME

摘要

The present invention relates to 6(4-substituted-anilino)pyrimidine derivatives useful as an antiviral agent, and more particularly novel 6(4- substituted-anilino)pyrimidine derivatives having an excellent inhibitory effect on replication of Hepatitis C virus; (HCV), represented by the following formula (I) in which R represents a C1-C4 straight or branched alkoxycarbonyl group, heterocycliccarbonyl group or carboxyalkyl group; and pharmaceutically acceptable salts thereof, a preparation method thereof, and an antiviral pharmaceutical composition comprising the compound as an effective ingredient. The 6(4-substituted-anilino)pyrimidine derivatives according to the present invention have an excellent inhibitory effect on replication of Hepatitis C virus (HCV) and thus can be advantageously used a s a therapeutic or prophylactic agent of hepatitis C.