发明名称 Pancreatic lipase inhibitor compounds, their synthesis and use
摘要 The subject invention features compounds having the structure: wherein X is O, S, CH<subscript>2 </highlight>or NR<subscript>5</highlight>; Y is O or S; R<subscript>1 </highlight>is H, substituted or unsubstituted C<subscript>1</highlight>-C<subscript>15 </highlight>alkyl, C<subscript>1</highlight>-C<subscript>8 </highlight>alkylaryl, -C(O)OR<subscript>4</highlight>, -C(O)NR<subscript>4</highlight>R<subscript>5</highlight>, -CR<subscript>6</highlight>R<subscript>6'</highlight>OR<subscript>4</highlight>, -CR<subscript>6</highlight>R<subscript>6'</highlight>OC(O)R<subscript>4</highlight>, -CR<subscript>6</highlight>R<subscript>6'</highlight>OC(O)NHR<subscript>7</highlight>, -C(O)NR<subscript>10</highlight>R<subscript>11</highlight>, -C(O)NR<subscript>8</highlight>R<subscript>9 </highlight>NR<subscript>8</highlight>R<subscript>9</highlight>, -N(R<subscript>5</highlight>)C(O)NHR<subscript>5</highlight>, or CH<subscript>2</highlight>R<subscript>4</highlight>; R<subscript>2 </highlight>is a substituted or unsubstituted, straight chain C<subscript>1</highlight>-C<subscript>30 </highlight>alkyl or branched C<subscript>3</highlight>-C<subscript>30 </highlight>alkyl, aryl, alkylaryl, arylalkyl, heteroarylalkyl or cycloalkyl; R<subscript>3 </highlight>is H or substituted or unsubstituted C<subscript>1</highlight>-C<subscript>6 </highlight>alkyl or C<subscript>3</highlight>-C<subscript>10 </highlight>cycloalkyl; R<subscript>4 </highlight>is H or a substituted or unsubstituted, straight chain or branched, C<subscript>6</highlight>-C<subscript>30 </highlight>alkyl, aryl, -CH<subscript>2</highlight>-aryl, aryl -C<subscript>1</highlight>-C<subscript>15 </highlight>alkyl, heteroaryl-C<subscript>1</highlight>-C<subscript>15</highlight>alkyl or C<subscript>3</highlight>-C<subscript>10 </highlight>cycloalkyl; R<subscript>5 </highlight>is H or a substituted or unsubstituted, straight chain or branched, C<subscript>6</highlight>-C<subscript>30 </highlight>alkyl, aryl C<subscript>1</highlight>-C<subscript>30</highlight>alkyl, heteroarylalkyl or cycloalkyl; R<subscript>6 </highlight>and R<subscript>6'</highlight> are each independently H, substituted or unsubstituted C<subscript>1</highlight>-C<subscript>6 </highlight>alkyl, dialkyl or C<subscript>3</highlight>-C<subscript>10 </highlight>cycloalkyl or together form a 3-7 membered ring system; R<subscript>7 </highlight>is H or substituted or unsubstituted C<subscript>1</highlight>-C<subscript>12 </highlight>alkyl or C<subscript>3</highlight>-C<su
申请公布号 US2003195199(A1) 申请公布日期 2003.10.16
申请号 US20020326302 申请日期 2002.12.20
申请人 WITTER DAVID;CASTELHANO ARLINDO 发明人 WITTER DAVID;CASTELHANO ARLINDO
分类号 A61K31/519;A61K31/5365;A61K31/542;A61P3/04;A61P3/06;A61P3/10;A61P43/00;C07B61/00;C07D333/38;C07D333/40;C07D409/12;C07D495/04;C07D498/02;C07D498/04;C07D513/02;C07D513/04;(IPC1-7):A61K31/542;A61K31/538 主分类号 A61K31/519
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