发明名称 |
MULTIMERS OF RECEPTOR-BINDING LIGANDS |
摘要 |
The invention relates to the provision of oligomeric polypeptides (dimers, trimers, etc) comprising the ligand binding domains of cytokines which are linked via flexible polypeptide linker molecules. The linker molecules optionally comprise protease sensitive sites to modulate the release of biologically active cytokines when administered to a human or animal subject. |
申请公布号 |
WO03062276(A3) |
申请公布日期 |
2003.10.16 |
申请号 |
WO2003GB00253 |
申请日期 |
2003.01.24 |
申请人 |
ASTERION LIMITED;ROSS, RICHARD;ARTYMIUK, PETER;SAYERS, JON |
发明人 |
ROSS, RICHARD;ARTYMIUK, PETER;SAYERS, JON |
分类号 |
C12N15/09;A61K38/00;A61K38/19;A61K48/00;A61P3/04;A61P3/06;A61P3/10;A61P5/00;A61P5/06;A61P7/06;A61P9/12;A61P13/12;A61P19/02;A61P19/10;A61P29/00;A61P31/04;A61P35/00;A61P37/06;C07K14/52;C07K14/575;C07K14/61;C07K14/715;C07K19/00;C12N1/15;C12N1/19;C12N1/21;C12N5/10;C12N15/10;C12N15/62;C12N15/63;C12P21/02 |
主分类号 |
C12N15/09 |
代理机构 |
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代理人 |
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主权项 |
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地址 |
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