METHOD FOR THE PRODUCTION OF CHIRAL IMIDAZOLIDIN-2-ONES

摘要

The invention relates to a method for producing chiral imidazolidin-2-ones of general formula I, in which R1 represents C1-C8-alkyl, cyclohexyl-, phenyl-, a phenyl radical substituted with C1-C6-alkyl-, halo-, nitro-, C1-C6-alkoxy-, C1-C6-alkylmercapto-, or CF3-, naphthyl-, or a naphthyl radical substituted with C1-C6-alkyl-, halo-, nitro-, C1-C6-alkoxy-, or CF3-, R2 represents C1-C8-alkyl-, C1-C8-alkenyl, cyclohexyl-, phenyl-, or a phenyl-C1-C6-alkyl radical which can be substituted with a nitro-, C1-C6-alkoxy-, methylendioxi-, or CF3 radical, and R3 represents C1-C12 alkyl-, C1-C8-alkenyl-, cyclohexyl-, phenyl-, or a phenyl radical substituted with C1-C6-alkyl-, halo-, nitro-, C1-C6-alkoxy, methylendioxi-, dialkylamine-, or CF3-, by reacting a compound of general formula II or the salt thereof, R1, R2, and R3 having the meaning indicated above, with urea in the presence of a non-volatile ammonium salt, said reaction being carried out in the presence of an aprotic polar organic solvent.