ENHANCER SEQUENCE OF THE 5-AMINOLEVULINIC SYNTHASE GENE

摘要

Nucleic acid sequences mediating chemical compound induced 5-aminolevulinatesynthase gene (ALAS1) expression are disclosed. Said sequences comprise at leasta DR-4 binding site. Furthermore, in vitro methods for testing chemical compounds formodulation of heme and/or P 450 cytochromes synthesis are described.