摘要 |
The 9-( beta -D-arabinofuranosyl)adenine 5'-phosphate is prepared from a mixture obtained by reaction of 9-( beta -D-arabinofuranosyl)adenine with a phosphorylating agent, in a trialkyl phosphate as solvent. The mixture is then subjected to an aqueous hydrolysis, the pH of the hydrolysis mixture is adjusted to a value sufficiently high to bring about separation into aqueous and nonaqueous liquid phases; the trialkyl phosphate, which is the solvent, is removed and then the product is precipitated so as to separate it from the residual aqueous mixture and it is isolated. |