发明名称 |
LIVER NECROSIS PREDICTIVE GENES |
摘要 |
The invention provides toxicity predictive genes that can be used to predict toxicity in response to one more agents. The invention provides for a method of predicting the liver toxicity in an individual to an agent. The method comprises obtaining a biological sample from an individual treated with the agent. The expression of one or more liver toxicity predictive genes in the sample is measured, wherein the genes are selected from a group consisting o f partial gene sequences of genes identified as responsive to agents causing liver necrosis. The process generates a test expression profile. The test expression profile is used with a set of reference expression profiles in a Predictive Model to determine whether the agent will induce liver toxicity i n the individual.
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申请公布号 |
CA2499636(A1) |
申请公布日期 |
2003.10.16 |
申请号 |
CA20032499636 |
申请日期 |
2003.04.01 |
申请人 |
PHASE-1 MOLECULAR TOXICOLOGY, INC. |
发明人 |
KIER, LARRY;DERBEL, MAHER;SANKAR, USHA;NOLAN, TIMOTHY D. |
分类号 |
C12Q1/68;(IPC1-7):G06F17/00 |
主分类号 |
C12Q1/68 |
代理机构 |
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