发明名称 |
TREATMENT OF NEURODEGENERATIVE DISORDERS THROUGH THE MODULATION OF THE POLYAMINE PATHWAY |
摘要 |
The present invention provides methods and compositions for modulating polyamine pathway activity as a means for ameliorating neurodegenarative disorders. In particular, for ameliorating the symptoms or onset of amyotrophic lateral sclerosis (ALS) by modulating the gene and protein products involved the polyamine pathway, such as by inhibiting the enzyme, ornithine decarboxylase (ODC), involved in the synthesis of the polyamine, putrescine. Compositions and methods are disclosed for inhibiting the polyamine pathway producing lower polyamine levels resulting in a beneficial effect on ALS. This can be accomplished by using modulating agents such as analogs, or polyamine analogs, and antiproliferative drugs. Screening assays for pharmacological agents that are capable of decreasing polyamine levels and/or reducing cell proliferation are also disclosed. |
申请公布号 |
WO03043616(A3) |
申请公布日期 |
2003.10.16 |
申请号 |
WO2002US35203 |
申请日期 |
2002.11.01 |
申请人 |
ALS THERAPY DEVELOPMENT FOUNDATION, INC. |
发明人 |
TENNORE, RAMESH, M.;SCOTT, SEAN |
分类号 |
A61K31/00;A61K31/13;A61K31/132;A61K31/135;A61K31/17;A61K31/198;A61K31/216 |
主分类号 |
A61K31/00 |
代理机构 |
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代理人 |
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主权项 |
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地址 |
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