发明名称 |
MULTINERS OF CLASS I MAJOR HISTOCOMPATIBILITY COMPLEXES CANTAINING MODIFIED BETA2-MICROGLOBULIN PROTEINS |
摘要 |
The present invention provides a multimers of class I Major Histocompatibility Complexes (MHCs) having a modified beta2-microglobulin whose binding to CD8 is inhibited. Such MHCs are capable of inhibiting CD8<+> T cell response, particularly by inducing apoptosis or anergy of the T cell. The invention also provides nucleic acids encoding such molecules, and the use of such multimers and nucleic acids in immunosuppressive therapy, in particular as inhibitors of cytotoxic T cell responses. |
申请公布号 |
WO02102840(A3) |
申请公布日期 |
2003.10.16 |
申请号 |
WO2002GB02866 |
申请日期 |
2002.06.19 |
申请人 |
AVIDEX LIMITED;JAKOBSEN, BENT, KARSTEN;BOULTER, JONATHAN, MICHAEL |
发明人 |
JAKOBSEN, BENT, KARSTEN;BOULTER, JONATHAN, MICHAEL |
分类号 |
A61K48/00;A61P37/06;C07K14/74;C12N15/12 |
主分类号 |
A61K48/00 |
代理机构 |
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代理人 |
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主权项 |
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地址 |
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