| 摘要 |
A method is provided for making and using an assay chip having a hydrophilic region bounded by a hydrophobic region. This is desirable because it allows the user to deposit reagents in an aqueous medium on the hydrophilic region while the hydrophobic region prevents the reagents from flowing away from the hydrophilic region. Hence, the reagents can be isolated in the hydrophilic region to minimize any loss or dilution of the reagents. In a preferred embodiment, the chip surface features a plurality of hydrophilic regions bounded by hydrophobic regions allowing the user to conduct a plurality of assays on the same chip without cross-contamination of the samples. This device is of particular interest to the field of genetic analysis in which oligonucleotides are attached to a gold electrode for electrochemical analysis.
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