| 摘要 |
The present invention relates to a method for targeting an agent towards a target site in a tissue comprising (a) administering to a tissue a multi-specific antibody (msAb) or multi-specific antibody fragment, comprising a targeting arm that binds to an antigen on the target site, and a capture arm that binds to a polymer conjugate; and (b) administering to the tissue a polymer conjugate that binds to the capture arm, with the polymer conjugate comprising a polymer conjugated to an agent selected from the group consisting of a therapeutic agent, a peptide, an enzyme and a labeled ligand. The present invention also relates to a kit, useful for targeting a target site in a tissue or tissue sample, comprising, (a) a multi-specific antibody or antibody fragment comprising a targeting arm that binds to an antigen on said target site, and a capture arm that binds to a polymer conjugate or hapten- polymer conjugate; and (b) a polymer conjugate that binds to the capture arm, with the polymer conjugate comprising a polymer conjugated to an agent selected from the group consisting of a therapeutic agent, a peptide, an enzyme and a labeled ligand. |
