发明名称 |
SYSTEMS AND METHODS FOR PREDICTING ACTIVE SITE RESIDUES IN A PROTEIN |
摘要 |
A system and method for predicting the active site residues in a target protein. The target protein, referred to interchangeably as the target amino sequence or the target sequence, is pairwise aligned with a set of query sequences. Using these multiple pairwise sequence alignments, residue positions within the target sequence which satisfy specified sequence-based criteria are identified as candidate active site positions. Candidate active site positions are mapped to a three-dimensional representation of the target sequence and filtered against structure-based criteria. Positions within the target sequence that satisfy both the sequence-based and structure-based criteria are predicted to be active site residues. |
申请公布号 |
WO03008551(A3) |
申请公布日期 |
2003.10.16 |
申请号 |
WO2002US22793 |
申请日期 |
2002.07.17 |
申请人 |
STRUCTURAL GENOMIX, INC.;GAJIWALA, KETAN, S. |
发明人 |
GAJIWALA, KETAN, S. |
分类号 |
G01N33/68;G06F19/16;G06F19/18;G06F19/22;(IPC1-7):G01N33/48 |
主分类号 |
G01N33/68 |
代理机构 |
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代理人 |
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主权项 |
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地址 |
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