| 摘要 |
Compositions comprising (a) a soy protein material containing at least 49% soy protein by dry weight of the soy protein material; and (b) a plant sterol that comprises at least 0.49 weight % of the composition. Independent claims are also included for: (1) compositions comprising: (a) at least one isoflavone chosen from genistein, daidzein, glycitein, biochanin A, formononetin and their naturally occurring glycosides and glycoside conjugates; and (b) a plant sterol that comprises at least 0.49 weight % of the composition; (2) compositions comprising (a) soy hypocotyl materials and (b) a plant sterol that comprises at least 0.49 weight % of the composition. ACTIVITY : Total blood cholesterol lowering; Low-density lipoprotein (LDL) blood cholesterol lowering; anti-atherosclerotic. Fifty subjects diagnosed with moderate to high hypercholesterolemia, e.g. having total blood cholesterol levels of 250 mg/dl or higher, are divided into 5 groups. The first group receives 30 g of isoflavone-free isolated soy protein dietary supplement, the second group receives 5 g of a plant sterol dietary supplement containing beta -sitosterol, the third group receives 75 mg of an isoflavone dietary supplement containing genistein and daidzein and the fourth receives a dietary supplement containing 30 g of soy protein, 5 g of beta -sitosterol, and 75 mg of genistein and daidzein (the combination group). The fifth group receives no dietary supplement (the control group). The diets of the groups contain no sources of isoflavones, plant sterols, and soy protein. The diets are continued for 6 months. Prior to starting the diets the total and LDL blood cholesterol levels of the patients are measured. The benchmarked symptoms are measured again for each group after the 6 month diet and the results are compared between members of each group. Enhanced activity in reducing LDL and total blood cholesterol levels by the combination of a plant sterol, a soy protein and an isoflavone is shown by a greater percent decrease of the LDL or blood cholesterol levels in the combination group relative to the other groups. MECHANISM OF ACTION : Antioxidant; tyrosine kinase inhibitor; bile acid sequestration; cholesterol absorption inhibitor; bile acid secretion promoter. |
