发明名称 |
Controlled-release sedative hypnotic compositions and method related thereto |
摘要 |
Controlled-release formulations providing a "pulsed" plasma profile of a sedative-hypnotic compounds having a particularly short half-life are provided. The formulation contains a sedative-hypnotic compound or precursor thereof that is metabolized to generate a sedative-hypnotic compound in vivo, wherein the compound has a mean plasma half life ranging from 0.1 to 2 hours; and at least one release retardant such that, following administration of the formulation to a patient, the patient has specific pulsed plasma profile for the sedative-hypnotic compound as disclosed herein. In a preferred embodiment, the sedative-hypnotic compound is NBI-34060. <IMAGE>
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申请公布号 |
EP1352647(A1) |
申请公布日期 |
2003.10.15 |
申请号 |
EP20030012600 |
申请日期 |
2000.08.28 |
申请人 |
NEUROCRINE BIOSCIENCES, INC. |
发明人 |
CAMPBELL, BRUCE D.;THIELE, W. JAY |
分类号 |
A61K9/22;A61K9/24;A61K9/50;A61K9/52;A61K31/519;A61K47/10;A61K47/14;A61K47/32;A61K47/34;A61K47/36;A61K47/38;A61K47/44;A61P25/20;C07D487/04;(IPC1-7):A61K9/22 |
主分类号 |
A61K9/22 |
代理机构 |
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代理人 |
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主权项 |
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地址 |
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