METHOD FOR IDENTIFICATION OF CHEMICAL SHIFT OF MULTIPLE COMPOSITE, METHOD FOR ANALYSIS OF THREE-DIMENSIONAL STRUCTURE OF MULTIPLE COMPOSITE, METHOD FOR CONSTRUCTION OF MODEL OF MULTIPLE COMPOSITE, NEW NUCLEIC ACID MOLECULE AND REAGENT

摘要

PROBLEM TO BE SOLVED: To provide a method in which a chemical shift of hydrogen atoms in a multiple composite is restored.

SOLUTION: (a) In the multiple composite, two or more molecules of the same kind are bonded in different positions to one polymer in a bonding form of the same kind. The multiple composite in which a chemical environment in a part bonded to one molecule on one terminal side is different from a chemical environment in a part bonded to one molecule on the other terminal side is prepared. (b) The chemical shift of the multiple composite under the condition (a) is measured, (c) (i) A measured value in which a difference is generated due to a difference in the chemical environment between bonding parts on both terminal sides of the polymer constituting the multiple composite under the condition (a) or (ii) a measured value in which a difference is generated due to a difference between a chemical environment of a single composite corresponding to a part in which one molecule in the multiple composite under the condition (a) is bonded to the polymer on one terminal side and a chemical environment of a single composite corresponding to a part in which one molecule in the multiple composite under the condition (a) is bonded to the polymer on the other terminal side is obtained. (d) On the basis of the measured value under the condition (c), the chemical shift measured under the condition (b) is identified.

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