Control of the ratio of LAP to LIP.

摘要

The present invention provides recombinant gene vectors and nucleic acid constructs which are capable of decreasing, reducing or suppressing the transcription/translation of LIP (transcription inhibitor protein), and in some examples, without affecting the transcription/translation of LAP (transcription activator). Such vectors and constructs are used in methods for increasing the ratio of LAP to LIP activity in a cell and for treating and/or ameliorating the symptoms of a disease or condition associated with the ratio of LAP to LIP. The present invention also provides methods for screening for agents that are capable of modifying the ratio of LAP to LIP activity in a cell or individual.