Tricyclic and heterocyclic compounds and medicament based thereon

摘要

Tri- heterocyclic compound of formula (I) wherein each of W, X and Y is carbon or nitrogen; each of U and Z is CR<2>, NR<13>, nitrogen, oxygen, sulfur etc.; A ring is carbocyclic ring, heterocyclic ring; R<1> is alkyl, alkenyl, alkynyl, NR<4>R<5>, OR<6> etc.; R<3> is carbocyclic ring, heterocyclic ring; and a pharmaceutically acceptable salt thereof, a process for the preparation thereof, a pharmaceutical comprising them as an active ingredient. A compound of formula (I) is useful, in order to possess corticotropin releasing factor receptor antagonistic activity, for the prevention and/or treatment of depression, anxiety, eating disorder, posttraumatic stress disorder, peptic ulcer, irritable bowl syndrome, Alzheimer's disease, drug addiction or alcohol dependence syndrome etc.