PROCESS FOR PRODUCING SUBSTANCE BY USING MICROBIAL CATALYST

摘要

An industrially advantageous process for producing a substance wherein the production speed of a reaction product in a reaction with the use of a microbial catalyst can be maintained at a constant level over a long period of time. In a reaction with the use of a microbial catalyst (for example, resting cells of an arthrobacter capable of converting a-hydroxynitriles into the corresponding a-hydroxy acid amides or a-hydroxy acid ammonium salts), the substance is produced at a constant speed by adding the substrate at a constant speed, regulating the concentration of the microbial catalyst in the liquid reaction mixture at a constant level and controlling the temperature so as to rise the reaction temperature at the point that the enzymatic activity of the microbial catalyst is lowered in the course of the reaction so as to maintain the reaction speed at a constant level.