Novel 2-hydroxymorpholines, medicaments containing these compounds, and processes for their preparation

摘要

The invention relates to novel 2-hydroxymorpholines of the general formula <IMAGE> in which A is an n-alkyl group which is optionally mono- or disubstituted by methyl or ethyl groups, R1 is a thiazolyl group which is optionally substituted by a halogen atom, or a trifluoromethyl or alkyl group, a phenyl group which is optionally substituted by one or two halogen atoms, or a trifluoromethyl, cyano, alkyl or alkoxy group, a phenyl group which is substituted by a halogen atom and by an alkyl or alkoxy group, a phenyl group which is substituted by an alkyl group and by an alkoxy group or an aminophenyl group which is substituted by one or two halogen atoms, a cyano group or by a halogen atom and by a cyano group, R2 is a hydrogen atom or a thiazolyl group which is optionally substituted by a halogen atom, or a trifluoromethyl or alkyl group and R3 is a hydroxyl, alkoxy, carboxyl, alkoxycarbonyl, aminocarbonyl, alkylaminocarbonyl or dialkylaminocarbonyl group, an alkoxy group which is substituted at the end by a carboxyl, alkoxycarbonyl, aminocarbonyl, alkylaminocarbonyl or dialkylaminocarbonyl group, an alkoxy group which is substituted at the end by a hydroxyl, alkoxy, phenylalkoxy, amino, alkylamino, dialkylamino, pyrrolidino, piperidino or hexamethyleneimino group, or an ethenylene group which is optionally substituted by an alkyl group and which ... Original abstract incomplete.