发明名称 Water-soluble compositions of bioactive lipophilic compounds
摘要 Water-soluble compositions comprising a lipophilic compound and a solubilizing agent of the general formula:</PTEXT>wherein:</PTEXT>X is a residue of a hydrophobic moiety,</PTEXT>Y is a residue of a hydrophilic moiety,</PTEXT>p is 1 or 2,</PTEXT>m is 0 or 1, and</PTEXT>n is an integer greater than or equal to 0</PTEXT>are disclosed. The lipophilic compound is preferably selected from the group consisting of water-insoluble ubiquinones, ubiquinols, vitamins, provitamins, polyene macrolide antibiotics, and mixtures thereof. The hydrophobic moiety is preferably a sterol or a tocopherol and the hydrophilic moiety is preferably a polyalkylene glycol. In some embodiments, the sterol is cholesterol or sitosterol, the tocopherol is alpha-(+)-tocopherol, the polyalkylene glycol is a polyethylene glycol or its methyl monoether having an average molecular weight between 400 and 1000, p is equal to 1 or 2, m is equal to 0 or 1 and n is an integer between 2 and 18.</PTEXT>
申请公布号 US6632443(B2) 申请公布日期 2003.10.14
申请号 US20010773592 申请日期 2001.02.02
申请人 NATIONAL RESEARCH COUNCIL OF CANADA 发明人 BOROWY-BOROWSKI HENRYK;SIKORSKA-WALKER MARIANNA;WALKER P. ROY
分类号 A61K9/00;A61K9/14;A61K31/01;A61K31/015;A61K31/045;A61K31/047;A61K31/122;A61K31/355;A61K31/7048;A61K35/60;A61K36/18;A61K47/12;A61K47/28;A61K47/30;A61P31/10;(IPC1-7):A61K9/00;A61K9/48;A61K9/20;A01N43/04;A01N25/00;C07H17/08 主分类号 A61K9/00
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