POTENT ONCOLYTIC HERPES SIMPLEX VIRUS FOR CANCER THERAPY

摘要

The present invention is directed to an oncolytic Herpes Simplex Virus havin g multiple cell membrane fusion mechanisms and preferably comprising a strict late viral promoter for effective conditional replication, such as in a malignant cell. In specific embodiments, the cell membrane fusion mechanisms are either from a mutant virus generated through random mutagenesis or throu gh insertion of a fusogenic membrane glycoprotein, and in further specific embodiments the strict late viral promoter UL38p regulates expression of the glycoprotein.