发明名称 |
EHANCED PROTEIN EXPRESSION IN BACILLUS |
摘要 |
The present invention provides cells that have been genetically manipulated to have an altered capacity to produce expressed proteins. In particular, the present invention relates to Gram-positive microorganisms, such as Bacillus species having enhanced expression of a protein of interest, wherein one or more chromosomal genes have been inactivated, and preferably wherein one or more chromosomal genes have been deleted from the Bacillus chromosome. In so me further embodiments, one or more indigenous chromosomal regions have been deleted from a corresponding wild-type Bacillus host chromosome. |
申请公布号 |
CA2480277(A1) |
申请公布日期 |
2003.10.09 |
申请号 |
CA20032480277 |
申请日期 |
2003.03.28 |
申请人 |
GENENCOR INTERNATIONAL, INC. |
发明人 |
RASHID, M. HARUNUR;HARBISON, CAROLE;FERRARI, EUGENIO;WEYLER, WALTER |
分类号 |
C12N15/09;C07K14/32;C12N1/21;C12N9/12;C12N9/16;C12N9/18;C12N9/20;C12N9/26;C12N9/42;C12N9/54;C12N9/56;C12N9/88;C12N9/90;C12N15/75;C12R1/125 |
主分类号 |
C12N15/09 |
代理机构 |
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代理人 |
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主权项 |
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地址 |
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