发明名称 |
CDC25 PHOSPHATASE INHIBITORS |
摘要 |
The invention concerns novel cdc25 phosphatase inhibitors, and in particular cdc25-C, which correspond to the general formula (I) wherein: A represents a carbocyclic aryl radical optionally substituted 1 to 3 times by one or more radicals independently selected among a halogen atom and an alkyl, hydroxy, alkoxy, alkylthio or NR<1>R<2> radical wherein R<1> and R<2> represent a hydrogen atom or an alkyl radical or R<1> and R<2> form together with the nitrogen atom a heterocycle of 4 to 7 members comprising 1 to 2 heteroatoms, the members required to complete the heterocycle being selected independently among the CR<3>R<4>-, -O-, -S and NR<5>- radicals, R<3> and R<4> representing independently each time they are involved a hydrogen atom or an alkyl, hydroxy, alkoxy, amino, alkylamino or dialkylamino radical, and R5 representing independently each time it is involved a hydrogen atom or an alkyl radical, or A represents a phenyl radical substituted by a phenyl radical optionally substituted 1 to 3 times by one or more radicals selected independently among a halogen atom and an alkyl, hydroxy, alkoxy, alkylthio or NR<1>R<2> radical wherein R<1> and R<2> represent a hydrogen atom or an alkyl radical; B represents a -(CH2)i-(CO)- or -NH-CO-(CH2)n or -(CH2)p and i and n being integers from 0 to 2 and p being an integer from 0 to 1; W represents a hydrogen atom or an alkyl radical; X represents a -(CH2)q- or (CH2)j-CO-(CH2)r-, q being an integer from 1 to 4 and j and r being integers from 0 to 6; Y represents in particular a nitrophenyl, aminophenyl, alkylaminophenyl or dialkylaminophenyl radical or the radical (T). |
申请公布号 |
WO0209686(A3) |
申请公布日期 |
2003.10.09 |
申请号 |
WO2001FR02443 |
申请日期 |
2001.07.26 |
申请人 |
SOCIETE DE CONSEILS DE RECHERCHES ET D'APPLICATIONS SCIENTIFIQUE (S.C.R.A.S.);PREVOST, GREGOIRE;BREZAK PANNETIER, MARIE-CHRISTINE;GALCERA CONTOUR, MARIE-ODILE;THURIEAU, CHRISTOPHE;GOUBIN-GRAMATICA, FRANCOISE;DUCOMMUN, BERNARD;LANCO, CHRISTOPHE |
发明人 |
PREVOST, GREGOIRE;BREZAK PANNETIER, MARIE-CHRISTINE;GALCERA CONTOUR, MARIE-ODILE;THURIEAU, CHRISTOPHE;GOUBIN-GRAMATICA, FRANCOISE;DUCOMMUN, BERNARD;LANCO, CHRISTOPHE |
分类号 |
C07D295/12;A61K31/04;A61K31/137;A61K31/166;A61K31/18;A61K31/222;A61K31/24;A61K31/381;A61K31/4164;A61K31/445;A61K31/495;A61K31/63;A61K31/661;A61K31/6615;A61P17/14;A61P21/00;A61P25/00;A61P25/28;A61P31/12;A61P33/00;A61P35/00;A61P43/00;C07C69/157;C07C211/53;C07C215/78;C07C215/80;C07C217/84;C07C229/36;C07C235/66;C07C303/38;C07C311/08;C07C311/13;C07C311/21;C07C311/29;C07C311/37;C07D211/96;C07D233/84;C07D241/04;C07D295/135;C07D295/155;C07D295/192;C07D295/26;C07D333/22;C07D333/34;C07D333/38;C07F9/12 |
主分类号 |
C07D295/12 |
代理机构 |
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代理人 |
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地址 |
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