摘要 |
There is described the preparation of phenylphenol compounds of formula (I) by reaction of a keto compound of formula (3) with dioxolane of formula (4) and with an ammonium compound of formula (5) to form a beta-aminoketone compound of formula (6) (reaction step (I)), reaction of the compound of formula (6) with a compound of formula (7) to form a compound of formula (2) (reaction step (II)), and subsequent alkylation to form a compound of formula (I) (reaction step (III)) in accordance with scheme (A); wherein R1, R2, R3, R6 and R7 are each independently of the others hydrogen or C1-C8-alkyl; R4, R5 and R8 are each independently of the others hydrogen or C1-C5alkyl; and Hal is a halogen atom. The compounds prepared in accordance with the invention are suitable as antimicrobial active substances. <chemistry-cwu id="CHEM-US-00002"> <number>2</number> <image id="EMI-C00002" he="137.781" wi="193.71555" file="US20030191349A1-20031009-C00002.TIF"/> <chemistry-chemdraw-file id="CHEMCDX-00002" file="US20030191349A1-20031009-C00002.CDX"/> <chemistry-mol-file id="CHEMMOL-00002" file="US20030191349A1-20031009-C00002.MOL"/> </chemistry-cwu>
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