发明名称 |
Method and apparatus for performing biological reactions on a substrate surface |
摘要 |
The present invention provides a method and an improved apparatus for removing gas bubbles from a reaction chamber comprising a flexible layer removably affixed to a substrate layer having a multiplicity of oligonucleotide binding sites disposed thereon, in which biological reactions are performed. The invention specifically relates to methods and apparatus for removing gas bubbles from a reaction chamber wherein target molecules contained in a sample fluid are reacted with probe molecules immobilized on a substrate having an array of oligonucleotide binding sites. The arrays are covered with a flexible, gas permeable layer that permits mixing of the sample fluid on the biochip and removal of gas bubbles from the fluid by use of a means for facilitating diffusion of gas bubbles across the flexible, gas permeable layer.
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申请公布号 |
US2003190744(A1) |
申请公布日期 |
2003.10.09 |
申请号 |
US20030394484 |
申请日期 |
2003.03.20 |
申请人 |
MOTOROLA;AMERSHAM |
发明人 |
MCGARRY MARK W.;JOHNSON W. TRAVIS;HAWKINS GEORGE W. |
分类号 |
G01N33/53;B01L3/00;B01L9/00;C07B61/00;C12M1/00;C12N15/09;C12Q1/68;C40B40/06;G01N21/05;G01N35/00;G01N37/00;(IPC1-7):C12M1/34 |
主分类号 |
G01N33/53 |
代理机构 |
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代理人 |
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主权项 |
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地址 |
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