FUMARIC ACID AMIDES

摘要

The invention relates to the use of fumaric acid amides of general formula (1) wherein R1 represents OR3 or a D- or L- amino acid radical NH-CHR4-COOH bound by an amide bond, wherein R3 is hydrogen, a straight-chained or branched, optionally substituted C1-24-alkyl radical, phenyl radical or a C6-10 aralkyl radical and R4 is a sidechain of a natural or synthetic amino acid, and R2 represents a D- or L- amino acid radical bound by an amide bond NH-CHR5 COOH or a peptide radical bound by an amide bond having 2-100 amino acids, wherein R5 is a side chain of a natural or synthetic amino acid, in the production of a medicament (1) for therapy of an auto-immune disease, (2) for use in transplantation medicine, (3) for therapy of mitochondrial diseases, selected from the group consisting of Parkinson syndrome, Alzheimer's disease, Huntingdon's chorea disease, retinopathia pigmentosa or mitochondrial encephalomypathy and (4) for therapy of NfkappaB mediated diseases.