METHODS AND COMPOSITIONS FOR DIAGNOSIS AND TREATMENT OF VASCULAR CONDITIONS

摘要

The present invention is directed to methods and compositions for the diagnosis and treatment of vascular conditions, particularly diabetes and atherosclerosis. The present invention comprises methods and compositions for determining the expression or activity of enzymes effecting HSPG, preferably, heparanase (Figures 4A-D) . The invention also comprises methods and compositions for treatment of vasculophathic diseases comprising administration of therapeutic compounds that are effective in inhibiting the expression or activity of heparanase.