发明名称 System and method of fluorescence spectroscopic imaging for characterization and monitoring of tissue damage
摘要 A method for monitoring a biological tissue includes illuminating the tissue, including a fluorophore, with a wavelength of light, the wavelength selected for exciting the fluorophore, determining a fluorescent emission of the fluorophore, the emission indicating the presence of the fluorophore, and correlating an emission of the fluorophore to an extent and degree of damage to the tissue. Damage to the tissue includes a breakdown of the fluorophore, resulting in a reduced level of emission. The fluorophore can include one of collagen and elastin. The fluorophore can include tryptophan, nicotinamide adenine dinucleotide, flavin and porphyrin. Correlating the emission of the fluorophore to the extent and degree of damage further includes processing a correlation of the emission over time, controlling the power of a laser welder based on the processed correlation, and preventing overheating of the tissue by the laser welder.
申请公布号 US6631289(B2) 申请公布日期 2003.10.07
申请号 US20010767125 申请日期 2001.01.22
申请人 RESEARCH FOUNDATION OF CUNY 发明人 ALFANO ROBERT R.;TANG JING;HO PING PEI
分类号 A61B5/00;G01N21/64;(IPC1-7):A61B6/00 主分类号 A61B5/00
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