BIOSYNTHETIC BINDING PROTEIN FOR CANCER MARKER

摘要

PROBLEM TO BE SOLVED: To provide a single-chain Fv (sFv) polypeptide defining a binding site exhibiting the immunological binding properties of an immunoglobulin molecule which binds c-erbB-2 or a c-erbB-2-related tumor antigen.

SOLUTION: The single-chain Fv (sFv) polypeptide defines a binding site exhibiting the immunological binding properties of an immunoglobulin molecule which binds c-erbB-2 or a c-erbB-2-related tumor antigen. The sFv includes at least two polypeptide domains connected by a polypeptide linker spanning the distance between the C-terminus of one domain and the N-terminus of the other. The amino acid sequence of each of the polypeptide domains includes a set of complementarity determining regions (CDRs) interposed between a set of framework regions (FRs), and the cDRs confer immunological binding to the c-erbB-2 or c-erbB-2-related tumor antigen.

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