发明名称 |
Methods for treatment of disease-induced peripheral neuropathy and related conditions |
摘要 |
A method of treating disease-induced peripheral neuropathy comprises administering to a patient with disease-induced peripheral neuropathy an effective quantity of a purine derivative or analogue, a tetrahydroindolone derivative or analogue, or a pyrimidine derivative or analogue. If the compound is a purine derivative, the purine moiety can be guanine or hypoxanthine. The compound can induce peripheral nerve sprouting through the action of a neurotrophic factor such as nerve growth factor (NGF) without the occurrence of hyperalgesia. The peripheral nerve sprouting can be nociceptive nerve sprouting. The disease-induced peripheral neuropathy can be diabetic neuropathy or disease-induced peripheral neuropathy with another basis.
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申请公布号 |
US6630490(B2) |
申请公布日期 |
2003.10.07 |
申请号 |
US20010900844 |
申请日期 |
2001.07.06 |
申请人 |
NEOTHERAPEUTICS, INC. |
发明人 |
DIAMOND JACK;GLASKY ALVIN J. |
分类号 |
A61K31/404;A61K31/505;A61K31/513;A61K31/52;A61K31/522;C07D473/18;C07D473/30;(IPC1-7):A61K31/445;A61K31/405 |
主分类号 |
A61K31/404 |
代理机构 |
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代理人 |
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主权项 |
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地址 |
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