NOVEL QUATERNARY AMMONIUM DERIVATIVES, METHOD FOR PREPARING SAME AND PHARMACEUTICAL USE

摘要

Compounds of formula corresponding to either formula (Ia) or (Ib):wherein:M represents a molecule that can be used for the treatment or diagnosis of pathologies caused by attack on the cartilage,R1, R2 and R3 represent an alkyl group, or R1, R2 and R3, together with the nitrogen atom carrying them, form a heterocycle,X represents a (C1-C6)alkylene chain in which one or more -CH2- groups are optionally replaced by a sulphur atom, an oxygen atom, or an -NR-, -CO-, -CO-NH-, -CO2-, -SO- or -SO2- group,n represents 0 or 1,Hal represents a halogen atom,or,R4 represents an alkyl group,Hal represents a halogen atom,represents a molecule that can be used for the treatment or diagnosis of pathologies caused by attack on the cartilage, wherein the nitrogen atom may optionally be included in a saturated or unsaturated nitrogen-containing heterocyclic system, or included in a double bond; and pharmaceutical compositions thereof.