发明名称 |
MEDICAMENT WITH A PROTECTIVE EFFECT AGAINST OXIDATIVE-TOXIC SUBSTANCES, PARTICULARLY AGAINST CARDIOTOXIC SUBSTANCES |
摘要 |
The use of benzazepin-N-acetic acid derivatives which contain an oxo group in the a position to the nitrogen atom and are substituted in the 3 position by a 1-(carboxyalkyl)-cyclopentyl-carbonyl-amino radical, and of their salts and biolabile esters, for the prophylaxis and/or treatment of heart damage caused by cardiotoxic doses of medicaments or chemicals, in larger mammals and in particular humans. The invention is particularly applicable to the prophylaxis and/or treatment of heart damage, in particular to the myocardium, which may occur during cytostatic chemotherapy. The invention also includes the use of the afore-mentioned benzazepin-N-acetic acid derivatives for adjuvant treatment in therapies in which medicaments having oxidative-toxic side-effects are used, and the preparation of medicaments suitable for this prophylaxis and/or treatment or adjuvant treatment. |
申请公布号 |
PL353012(A1) |
申请公布日期 |
2003.10.06 |
申请号 |
PL20000353012 |
申请日期 |
2000.07.10 |
申请人 |
SOLVAY PHARMACEUTICALS GMBH |
发明人 |
ROZSA ZSUZSANNA;PAPP JULIUS GY.;THORMAHLEN DIRK;WALDECK HARALD |
分类号 |
C07D223/16;A61K31/55;A61K31/704;A61K45/00;A61K45/06;A61P9/00;A61P21/00;A61P35/00;A61P37/04;A61P39/02;A61P39/06 |
主分类号 |
C07D223/16 |
代理机构 |
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代理人 |
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主权项 |
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地址 |
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